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An optical circuit-switched network core has the potential to overcome the inherent challenges of a conventional electrical packet-switched core of today's compute clusters. As optical circuit switches (OCS) directly handle the photon beams without any optical-electrical-optical (O/E/O) conversion and packet processing, OCS-based network cores have the following desirable properties: a) agnostic to data-rate, b) negligible/zero power consumption, c) no need of transceivers, d) negligible forwarding latency, and e) no need for frequent upgrade. Unfortunately, OCS can only provide point-to-point (unicast) circuits. They do not have built-in support for one-to-many (multicast) communication, yet multicast is fundamental to a plethora of data-intensive applications running on compute clusters nowadays. In this paper, we propose Shufflecast, a novel optical network architecture for next-generation compute clusters that can support high-performance multicast satisfying all the properties of an OCS-based network core. Shufflecast leverages small fanout, inexpensive, passive optical splitters to connect the Top-of-rack (ToR) switch ports, ensuring data-rate agnostic, low-power, physical-layer multicast. We thoroughly analyze Shufflecast's highly scalable data plane, light-weight control plane, and graceful failure handling. Further, we implement a complete prototype of Shufflecast in our testbed and extensively evaluate the network. Shufflecast is more power-efficient than the state-of-the-art multicast mechanisms. Also, Shufflecast is more cost-efficient than a conventional packet-switched network. By adding Shufflecast alongside an OCS-based unicast network, an all-optical network core with the aforementioned desirable properties supporting both unicast and multicast can be realized. 

DNA nanotechnology has proven exceptionally apt at probing and manipulating biological environments as it can create nanostructures of almost arbitrary shape that permit countless types of modifications, all while being inherently biocompatible. Emergent areas of particular interest are applications involving cellular membranes, but to fully explore the range of possibilities requires interdisciplinary knowledge of DNA nanotechnology, cell and membrane biology, and biophysics. In this review, we aim for a concise introduction to the intersection of these three fields. After briefly revisiting DNA nanotechnology, as well as the biological and mechanical properties of lipid bilayers and cellular membranes, we summarize strategies to mediate interactions between membranes and DNA nanostructures, with a focus on programmed delivery onto, into, and through lipid membranes. We also highlight emerging applications, including membrane sculpting, multicell self-assembly, spatial arrangement and organization of ligands and proteins, biomechanical sensing, synthetic DNA nanopores, biological imaging, and biomelecular sensing. Many critical but exciting challenges lie ahead, and we outline what strikes us as promising directions when translating DNA nanostructures for future in vitro and in vivo membrane applications.